T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune
responses to mediate inflammation and regulate other types of immune cells. Work in the …

Fibroblasts play an essential role in organogenesis and the integrity of tissue architecture
and function. Growth in most solid tumors is dependent upon remodeling 'stroma', composed …

Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …

Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

The tumour microenvironment is the primary location in which tumour cells and the host
immune system interact. Different immune cell subsets are recruited into the tumour …

Studies have reported a positive correlation between elevated CD8+ T cells in the tumor
microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T …

T cell proliferation and cytokine production are bioenergetically and biosynthetically costly.
The inability to meet these metabolic demands results in altered differentiation …

The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent
factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against …

Glioblastoma is an immunosuppressive, fatal brain cancer that contains glioblastoma stem-
like cells (GSCs). Oncolytic herpes simplex virus (oHSV) selectively replicates in cancer …