Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …

The rate of progression of HIV disease may be substantially different among HIV-infected
individuals. Following infection of the host with any virus, the delicate balance between virus …

Mathematical models, which are based on a firm understanding of biological interactions,
can provide nonintuitive insights into the dynamics of host responses to infectious agents …

Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the
acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking …

Monotherapy with (−) 2′, 3′-dideoxy-3′-thiacytidine (3TC) leads to the appearance of a
drug-resistant variant of human immunodeficiency virus-type 1 (HIV-1) with the methionine …

Reviews a large body of experimental data on the flexibility of T-cell receptor (TCR)
recognition. Conclusion that flexibility may in fact play an essential part in a T-cell …

The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a small integral
membrane phosphoprotein with two established functions: degradation of the viral …

Escape mutations are believed to be important contributors to immune evasion by rapidly
evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific …

Down-regulation of the initial burst of viremia during primary HIV infection is thought to be
mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this …

Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence
suggests that viral evolution in response to specific selective pressures follows generally …