Heterocyclic compounds: pharmacology of pyrazole analogs from rational structural considerations

RF Costa, LC Turones, KVN Cavalcante… - Frontiers in …, 2021 - frontiersin.org
Low quality of life and life-threatening conditions often demand pharmacological screening
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …

Current progress on antioxidants incorporating the pyrazole core

VLM Silva, J Elguero, AMS Silva - European journal of medicinal chemistry, 2018 - Elsevier
The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …

Insights into the Pharmacological Activity of the Imidazo− Pyrazole Scaffold

A Spallarossa, F Rapetti, MG Signorello… - …, 2023 - Wiley Online Library
In previous studies, we synthesized different imidazo− pyrazoles 1 and 2 with interesting
anticancer, anti‐angiogenic and anti‐inflammatory activities. To further extend the structure …

Novel vanillin derivatives: Synthesis, anti-oxidant, DNA and cellular protection properties

M Scipioni, G Kay, I Megson, PKT Lin - European journal of medicinal …, 2018 - Elsevier
Antioxidants have been the subject of intense research interest mainly due to their beneficial
properties associated with human health and wellbeing. Phenolic molecules, such as …

Synthesis and DFT Calculations of Novel Vanillin-Chalcones and Their 3-Aryl-5-(4-(2-(dimethylamino)-ethoxy)-3-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1 …

LA Illicachi, JJ Montalvo-Acosta, A Insuasty, J Quiroga… - Molecules, 2017 - mdpi.com
Novel (E)-1-(aryl)-3-(4-(2-(dimethylamino) ethoxy)-3-methoxyphenyl) prop-2-en-1-ones 4
were synthesized by a Claisen-Schmidt reaction of 4-(2-(dimethylamino) ethoxy)-3-methoxy …

A new approach for the synthesis and biological activities of novel thiazolyl‐pyrazole derivatives

GS Masaret - ChemistrySelect, 2021 - Wiley Online Library
According to the encouraging biological activity and low cytotoxicity profile of thiazolyl‐
pyrazole hybrid, many researchers are making efforts in this research area. 2‐(2‐(5‐Acetyl …

Phenolic thiazoles with antioxidant and antiradical activity. Synthesis, in vitro evaluation, toxicity, electrochemical behavior, quantum studies and antimicrobial …

G Marc, A Stana, AH Franchini, DC Vodnar, G Barta… - Antioxidants, 2021 - mdpi.com
Oxidative stress represents the underlying cause of many chronic diseases in human;
therefore, the development of potent antioxidant compounds for preventing or treating such …

Synthesis, Bioevaluation, Structure-Activity Relationship and Docking Studies of Natural Product Inspired (Z)-3-benzylideneisobenzofuran-1(3H)-ones as Highly …

BRK Shyamlal, L Yadav, MK Tiwari, M Mathur… - Scientific Reports, 2020 - nature.com
For the first time, a series of highly potent natural product inspired substituted (Z)-3-
benzylideneisobenzofuran-1 (3H)-ones 28a-t, embraced with electron-withdrawing groups …

Synthesis and molecular docking of N′-arylidene-5-(4-chlorophenyl)-1-(3, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbohydrazides as novel hypoglycemic and …

E Hernández-Vázquez, S Salgado-Barrera… - Bioorganic & medicinal …, 2016 - Elsevier
Herein, the design and synthesis of 10 novel N′-arylidene pyrazole-3-carbohydrazides are
described. Compounds were pretended to act as dual agents against diabetes and oxidative …

A regioselective synthesis of 3, 4-diaryl-1 H-pyrazoles through a 1, 3-dipolar cycloaddition of tosylhydrazones and nitroalkenes

CD García-Mejía, E Hernández-Vázquez… - Organic & …, 2023 - pubs.rsc.org
A procedure for the selective synthesis of 3, 4-diaryl-1H-pyrazoles through a 1, 3-dipolar
cycloaddition is reported. The transformation occurred under mild conditions using …