Replacement in angiogenesis research: Studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches

MW Laschke, Y Gu, MD Menger - Frontiers in physiology, 2022 - frontiersin.org
Angiogenesis, the development of new blood vessels from pre-existing ones, is an essential
process determining numerous physiological and pathological conditions. Accordingly …

Spatiotemporal multi-scale modeling of radiopharmaceutical distributions in vascularized solid tumors

M Kiani Shahvandi, M Soltani, F Moradi Kashkooli… - Scientific reports, 2022 - nature.com
We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal
distributions within vascularized solid tumors. The novelty of the presented model is at …

Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue

V Kopylova, S Boronovskiy, Y Nartsissov - Biophysical Reviews, 2023 - Springer
The cardiovascular system plays a key role in the transport of nutrients, ensuring a
continuous supply of all cells of the body with the metabolites necessary for life. The blood …

Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration

KM Wisdom, J Suijker, L Van den Broek… - ALTEX-Alternatives to …, 2023 - altex.org
Lung cancer is a leading cause of death worldwide, with only a fraction of patients
responding to immunotherapy. The correlation between increased T-cell infiltration and …

Mathematical simulation and prediction of tumor volume using RBF artificial neural network at different circumstances in the tumor microenvironment

M Akbarpour Ghazani, M Saghafian… - Proceedings of the …, 2021 - journals.sagepub.com
Uncontrolled proliferation of cells in a tissue caused by genetic mutations inside a cell is
referred to as a tumor. A tumor which grows rapidly encounters a barrier when it grows to a …

Capillary network formation and structure in a modified discrete mathematical model of angiogenesis

M Soltani - Biomedical Physics & Engineering Express, 2021 - iopscience.iop.org
Angiogenesis, as part of cancer development, involves hierarchical complicated events and
processes. Multiple studies have revealed the significance of the formation and structure of …

Transport of vascular endothelial growth factor dictates on-chip angiogenesis in tumor microenvironment

J Priyadarshani, P Awasthi, P Karan, S Das… - Physics of …, 2021 - pubs.aip.org
On-chip investigations on tumor angiogenesis, hallmarked by the growth of new blood
vessels from preexisting ones, have attracted significant interest in recent times, due to their …

Vascularized organoid-on-a-chip: design, imaging, and analysis

T Yu, Q Yang, B Peng, Z Gu, D Zhu - Angiogenesis, 2024 - Springer
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep
layers of organoids and provide a more physiologically relevant system in vitro. Common …

A novel numerical and artificial intelligence based approach to study anti-angiogenic drugs: Endostatin

MA Ghazani, M Soltani, P Jalali… - Applied Mathematical …, 2022 - Elsevier
Angiogenesis is known as the key factor in vascular tumor growth. In addition to furnishing
the tumor with fresh nutrients to survive and spread to the other tissues, tumor-induced …

[PDF][PDF] Effect of PEGylated gold nanorods on the circulating vascular endothelial growth factor, platelet-derived growth factor, and miR-29a in CD-1 mice.

AM Gamal-Eldeen, BM Raafat, CA Fahmy… - Journal of the National …, 2022 - nsf.ac.lk
Gold nanorods (GNRs) show promising biomedical therapeutic/imaging applications. This
study investigated the effect of PEGylated-GNRs on the angiogenesis factors: vascular …