Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Effective reprogramming of chronic wound healing remains challenging due to the limited
drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Cancer-associated fibroblasts (CAFs) are integral to the solid tumor microenvironment.
CAFs were once thought to be a relatively uniform population of matrix-producing cells, but …

Various factors could damage the structure and integrity of skin to cause wounds.
Nonhealing or chronic wounds seriously affect the well-being of patients and bring heavy …

Wound healing is a dynamic and highly sequential process involving a series of overlapping
spatial and temporal phases, including hemostasis, inflammation, proliferation, and tissue …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …