The Caco-2 cell model has been widely used to assess the permeability of drug candidates.
It has provided a high throughput in vitro platform, functionally resembling the enterocytes …

One of the main goals of in silico Caco-2 cell permeability models is to identify those drug
substances with high intestinal absorption in human (HIA). For more than a decade, several …

The Caco-2 cellular monolayer is a widely accepted in vitro model to predict human
permeability but suffering from several and critical limitations. Therefore, some alternative …

Caco-2 monolayers are a common in vitro model used to evaluate human intestinal
absorption. The reference protocol requires 21 days post-seeding to establish a stable and …

New organometallic gold (III) and platinum (II) complexes containing iminophosphorane
ligands are described. Most of them are more cytotoxic to a number of human cancer cell …

Hydrogels are widely studied as drug delivery system. In this work we propose the
employment of tetrakis (hydroxymethyl) phosphonium chloride as crosslinking agent to …

The present study aims to validate the anticancer potential of the phytocompounds namely
carvacrol, thymol, alpha pinene, limonene, vanillin, cineole and syringic acid against …

Usually, duodenal barriers are investigated using intestinal cell lines like Caco‐2, which in
contrast to native tissue are limited in cell‐type representation. Organoids can consist of all …

The heterogeneity of the Caco-2 cell line and differences in experimental protocols for
permeability assessment using this cell-based method have resulted in the high variability of …

The lack of accessibility to normal and diseased human intestine and the inability to
separate the different functional compartments of the intestine even when tissue could be …