Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesis

KA Simanek, ML Schumacher, CP Mallery… - Nature …, 2023 - nature.com
Quorum sensing is a mechanism of bacterial communication that controls virulence gene
expression. Pseudomonas aeruginosa regulates virulence via two synthase/transcription …

Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in Pseudomonas aeruginosa

CM Schwartzkopf, VL Taylor, MC Groleau… - Molecular …, 2024 - Wiley Online Library
Quorum sensing, a bacterial signaling system that coordinates group behaviors as a
function of cell density, plays an important role in regulating viral (phage) defense …

Genetic and transcriptomic characteristics of RhlR-dependent quorum sensing in cystic fibrosis isolates of Pseudomonas aeruginosa

KL Asfahl, NE Smalley, AP Chang, AA Dandekar - Msystems, 2022 - Am Soc Microbiol
In people with the genetic disease cystic fibrosis (CF), bacterial infections involving the
opportunistic pathogen Pseudomonas aeruginosa are a significant cause of morbidity and …

Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation

P Jayakumar, ART Figueiredo, R Kümmerli - Msystems, 2022 - Am Soc Microbiol
Pseudomonas aeruginosa populations evolving in cystic fibrosis lungs, animal hosts, natural
environments and in vitro undergo extensive genetic adaption and diversification. A …

Frequency of quorum-sensing mutations in Pseudomonas aeruginosa strains isolated from different environments

K O'Connor, CY Zhao, M Mei, SP Diggle - Microbiology, 2022 - microbiologyresearch.org
Pseudomonas aeruginosa uses quorum sensing (QS) to coordinate the expression of
multiple genes necessary for establishing and maintaining infection. It has previously been …

Uncovering the GacS-mediated role in evolutionary progression through trajectory reconstruction in Pseudomonas aeruginosa

B Jiang, H Qiu, C Lu, M Lu, Y Li… - Nucleic Acids Research, 2024 - academic.oup.com
The genetic diversities of subpopulations drive the evolution of pathogens and affect their
ability to infect hosts and cause diseases. However, most studies to date have focused on …

The Relationship of pqs Gene Expression to Acylhomoserine Lactone Signaling in Pseudomonas aeruginosa

MP Soto-Aceves, NE Smalley, AL Schaefer… - bioRxiv, 2024 - biorxiv.org
The opportunistic pathogen Pseudomonas aeruginosa has complex quorum sensing (QS)
circuitry, which involves two acylhomoserine lactone (AHL) systems, the LasI AHL synthase …

Quorum sensing as the microbial expression of a bioethics for mars colonisation

A Araújo - Frontiers in Astronomy and Space Sciences, 2023 - frontiersin.org
Quorum sensing (QS) may be understood and applied as a chemical grammar for
ecocommunity interaction on Mars. Such interaction radiates a disruptive technology …