Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Scientific evidence collected over the past 4 decades suggests that a loss of cholinergic
innervation in the cerebral cortex of patients with Alzheimer's disease is an early pathogenic …

Decreased olfactory function is very common in the older population, being present in over
half of those between the ages of 65 and 80 years and in over three quarters of those over …

It has been well established that neuronal loss within the cholinergic nucleus basalis of
Meynert (nbM) correlates with cognitive decline in dementing disorders such as Alzheimer's …

Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to
play a critical role in the development of AD neuropathology. The overexpression of the …

The cholinergic hypothesis of cognitive impairment and Alzheimer's disease has been for
decades a “polar star” for studies on dementia and neurodegenerative diseases. Aim of the …

Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …

Progressing gradually from babbling to meaningful sentences is something most babies do
naturally. But why do they? John L. Locke's answer constitutes a fascinating journey along …

The nucleus basalis (NB) of the human brain is a large, complex, and highly differentiated
structure. Many of its neurons are magnocellular, hyperchromic, isodendritic …

Alzheimer's disease (AD) is the most common cause of dementia that arises on a
neuropathological background of amyloid plaques containing β-amyloid (Aβ) derived from …