Gold (III) complexes in medicinal chemistry

PI da Silva Maia, VM Deflon, U Abram - Future medicinal chemistry, 2014 - Taylor & Francis
A number of gold (III) compounds has been designed with the objective of overcoming the
disadvantages associated with the platinum-based drugs for cancer treatment. Compounds …

Comparing the metal concentration in the hair of cancer patients and healthy people living in the Malwa region of Punjab, India

E Blaurock-Busch, YM Busch… - Clinical Medicine …, 2014 - journals.sagepub.com
The cancer prevalence in the Malwa region of Punjab (1089/million/year) is much higher
than the national average cancer prevalence in India (800/million/year). The participants in …

Gold Compounds Inhibit the Ca2+-ATPase Activity of Brain PMCA and Human Neuroblastoma SH-SY5Y Cells and Decrease Cell Viability

M Berrocal, JJ Cordoba-Granados, SAC Carabineiro… - Metals, 2021 - mdpi.com
Plasma membrane calcium ATPases (PMCA) are key proteins in the maintenance of
calcium (Ca2+) homeostasis. Dysregulation of PMCA function is associated with several …

Water-soluble gold (III) complexes with N-donor ligands as potential immunomodulatory and antibiofilm agents

NS Radulović, NM Stojanović, BĐ Glišić… - Polyhedron, 2018 - Elsevier
Six gold (III) complexes with ligands of differing denticity,[HGly-Met sulfoxide][AuCl 4](1b),[Au
(en) Cl 2] Cl· 2H 2 O (1c),[Au (dien) Cl] Cl 2 (1d),[Au (Gly-l-His) Cl] NO 3· 1.25 H 2 O (1e),[Au …

The Ca2+-ATPase Inhibition Potential of Gold(I, III) Compounds

C Fonseca, G Fraqueza, SAC Carabineiro, M Aureliano - Inorganics, 2020 - mdpi.com
The therapeutic applications of gold are well-known for many centuries. The most used gold
compounds contain Au (I). Herein, we report, for the first time, the ability of four Au (I) and Au …

[HTML][HTML] Effect of Fe3+ on Na, K-ATPase: unexpected activation of ATP hydrolysis

TGF Costa, MM Oliveira, MM Toledo, HB Santos… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Iron is a key element in cell function; however, its excess in iron overload conditions can be
harmful through the generation of reactive oxygen species (ROS) and cell oxidative stress …

The effect of cytochrome c on Na, K-ATPase

G Chkadua, E Nozadze, L Tsakadze… - Journal of Bioenergetics …, 2024 - Springer
Na, K-ATPase is a crucial enzyme responsible for maintaining Na+, K+-gradients across the
cell membrane, which is essential for numerous physiological processes within various …

Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(iii) complexes

AM Bondžić, GV Janjić, MD Dramićanin, L Messori… - Metallomics, 2017 - academic.oup.com
Na/K-ATPase is emerging as an important target for a variety of anticancer metal-based
drugs. The interactions of Na/K-ATPase (in its E1 state) with three representative and …

[PDF][PDF] Comparing the metal concentration in the nails of healthy and cancer patients living in the Malwa region of Punjab, India with a random European group-a …

E Blaurock-Busch, YM Busch, A Friedle… - British Journal of …, 2015 - microtrace.eu
The cancer prevalence in the Malwa region of Punjab (1089/million/year) is much higher
than the national average cancer prevalence in India (800/million/year). In our previous …

Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis (1, 2-diaminocyclohexane) gold (III) chloride compounds and their …

SS Al-Jaroudi, M Monim-Ul-Mehboob, M Altaf… - New Journal of …, 2014 - pubs.rsc.org
New gold (III) compounds with chemical formulae [Au {cis-(1, 2-DACH)} 2] Cl31,[Au {trans-
(±)-(1, 2-DACH)} 2] Cl32 and [Au {(S, S)-(+)-1, 2-(DACH)} 2] Cl33 (where 1, 2-DACH= 1, 2 …