Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Oncogenic Kras-activated pancreatic ductal adenocarcinoma (PDAC) cells highly rely on an
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …

Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually
changing microenvironment. We demonstrated that the dynamic posttranslational …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

The addition of O-linked-β-DN-acetylglucosamine (O-GlcNAc) onto serine and threonine
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …

O-GlcNAcylation is a conserved post-translational modification that attaches N-acetyl
glucosamine (GlcNAc) to myriad cellular proteins. In response to nutritional and hormonal …

Functional tools are needed to understand complex biological systems. Here we review how
chemical reporters in conjunction with bioorthogonal labeling methods can be used to …

Abstract O-linked N-acetylglucosamine (O-GlcNAc) is an essential and dynamic post-
translational modification that is presented on thousands of nucleocytoplasmic proteins …

Abstract O-linked β-DN-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto
serine and threonine residues of proteins is an important post-translational modification …