Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity—and thereby pave the way for …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …

Neuroscience has focused on the detailed implementation of computation, studying neural
codes, dynamics and circuits. In machine learning, however, artificial neural networks tend …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

To investigate circuit mechanisms underlying locomotor behavior, we used serial-section
electron microscopy (EM) to acquire a synapse-resolution dataset containing the ventral …

Retinal circuits transform the pixel representation of photoreceptors into the feature
representations of ganglion cells, whose axons transmit these representations to the brain …

High-resolution serial-section electron microscopy (ssEM) makes it possible to investigate
the dense meshwork of axons, dendrites, and synapses that form neuronal circuits …

Sensory experience remodels neural circuits in the early postnatal brain through
mechanisms that remain to be elucidated. Applying a new method of ultrastructural analysis …