Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …

Type 1 diabetes (T1D) is a multifactorial autoimmune disease driven by T-cells against the
insulin-producing islet β-cells, resulting in a marked loss of β-cell mass and function …

Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also
widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) …

CTLA-4 is a critical negative regulator of the immune system and a major target for
immunotherapy. However, precisely how it functions in vivo to maintain immune …

Background & Aims CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) are essential to
maintain immunological tolerance and have been shown to promote liver allograft tolerance …

Recently, increased interest in the use of Tregs as adoptive cell therapy for the treatment of
autoimmune diseases and transplant rejection had led to several advances in the field …

Regulatory T cells (Tregs) maintain immune equilibrium by suppressing immune responses
through various multistep contact dependent and independent mechanisms. Cellular …

Treg therapies are being tested in clinical trials in transplantation and autoimmune diseases,
however, the impact of inflammation on Tregs remains controversial. We challenged human …

Co-inhibitory receptors (IRs) are molecules that protect host against autoimmune reactions
and maintain peripheral self-tolerance, playing an essential role in maintaining immune …