The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA
damage response, but also in many cellular processes during unperturbed cell growth. The …

Abstract p21 Waf1 was identified as a protein suppressing cyclin E/A-CDK2 activity and was
originally considered as a negative regulator of the cell cycle and a tumor suppressor. It is …

Poisoning of DNA topoisomerase I is the mechanism by which camptothecins interfere with
tumor growth. Although the clinical use of camptothecins has had a significant impact on …

To assess genetoxicity and the underlying mechanisms of carbamazepine (CBZ) toxicity in
fish, adult Chinese rare minnows (Gobiocypris rarus) were exposed to 1, 10, and 100 μg/L …

AKI induced by CP chemotherapy remains an obstacle during patient treatments.
Extracellular signal-regulated protein kinases 1/2 (ERK), key participants in CP-induced …

Mitogen-activated protein kinases (MAPK) are involved in a complex network which
regulates a variety of cellular processes including proliferation, survival and death. The …

Apoptosis plays a crucial role in the pathogenesis of early brain injury (EBI) following
subarachnoid hemorrhage (SAH). However, the exact molecular mechanisms underlying …

DNA-damage response of cutaneous interfollicular melanocytes to fractionated radiotherapy
was investigated by immunostaining of tissue sections from punch biopsies collected before …

Diabetes is increasingly becoming a major cause of large-scale morbidity and mortality.
Diabetes-induced oxidative stress alters numerous intracellular signaling pathways …

Background Cutaneous melanoma is the most lethal skin cancer and its incidence in
developed countries has dramatically increased over the past decades. Localized tumors …