Recent advances of smart materials for ocular drug delivery

X Wang, F Luan, H Yue, C Song, S Wang… - Advanced Drug Delivery …, 2023 - Elsevier
Owing to the variety and complexity of ocular diseases and the natural ocular barriers, drug
therapy for ocular diseases has significant limitations, such as poor drug targeting to the site …

[HTML][HTML] Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

Q Zhang, Y Jiang, C Deng, J Wang - Frontiers in Medicine, 2024 - frontiersin.org
In the field of eye health, the profound impact of exercise and physical activity on various
ocular diseases has become a focal point of attention. This review summarizes and …

[HTML][HTML] Absent in Melanoma (AIM) 2 Promotes the Outcome of Islet Transplantation by Repressing Ischemia-Induced Interferon (IFN) Signaling

S Wrublewsky, C Wilden, C Bickelmann, MD Menger… - Cells, 2023 - mdpi.com
Clinical islet transplantation is limited by ischemia-induced islet cell death. Recently, it has
been reported that the absent in melanoma (AIM) 2 inflammasome is upregulated by …

Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in …

Y Li, L Tian, S Li, X Chen, F Lei, J Bao, Q Wu… - Free Radical Biology …, 2024 - Elsevier
Purpose Severe dry eye disease causes ocular surface damage, which is highly associated
with mitochondrial dysfunction. Mitochondrial transcription factor A (TFAM) is essential for …

[HTML][HTML] Metabolic activity of visceral adipose tissue is associated with age-related macular degeneration: a pilot 18F-FDG PET/CT study

KE Choi, C Joung, KJ Pahk, H Kim… - Frontiers in …, 2024 - frontiersin.org
Background Obesity is known to increase the risk and severity of age-related macular
degeneration (AMD). Increased inflamed metabolic activity of visceral adipose tissue (VAT) …

Activating MC4R Promotes Functional Recovery by Repressing Oxidative Stress-Mediated AIM2 Activation Post-spinal Cord Injury

Y Wang, N Fang, Y Wang, Y Geng, Y Li - Molecular Neurobiology, 2024 - Springer
Spinal cord injury (SCI) is a destructive neurological trauma that induces permanent sensory
and motor impairment as well as a deficit in autonomic physiological function. Melanocortin …

[HTML][HTML] Linking Adiponectin and Its Receptors to Age-Related Macular Degeneration (AMD)

M Choubey, MB Tirumalasetty, NS Bora, PS Bora - Biomedicines, 2023 - mdpi.com
In recent years, there has been a captivating focus of interest in elucidating the intricate
crosstalk between adiponectin (APN), a versatile fat-associated adipokine and ocular …

The Role of Adiponectin and its Receptor Signaling in Ocular Inflammation-associated Diseases

J Zheng, W Zhang, R Xu, L Liu - Biochemical and Biophysical Research …, 2024 - Elsevier
Ocular inflammation-associated diseases are leading causes of global visual impairment,
with limited treatment options. Adiponectin, a hormone primarily secreted by adipose tissue …

[PDF][PDF] Pivotal Roles of APN/AdipoRs Signaling in Maintaining Ocular Homeostasis and Protecting against Eye Ailments

M Choubey, MB Tirumalasetty, NS Bora, PS Bora - 2024 - researchgate.net
This comprehensive review critically examines the latest findings and breakthroughs that
underscore the pivotal roles of APN/AdipoRs signaling in maintaining ocular homeostasis …

Obesity Hormone Function in Aging Eyes: Linking Adiponectin and its Receptors to AMD

M Choubey, P Bora, NS Bora, PS Bora - 2023 - preprints.org
In recent years, the interaction between adiponectin (APN), a versatile fat-associated
adipokines, and eye disorders has become a captivating focus of interest. Unveiling the …