From input to output: the Lap/c-di-GMP biofilm regulatory circuit

AJ Collins, TJ Smith, H Sondermann… - Annual review of …, 2020 - annualreviews.org
Biofilms are the dominant bacterial lifestyle. The regulation of the formation and dispersal of
bacterial biofilms has been the subject of study in many organisms. Over the last two …

Type 1 does the two-step: type 1 secretion substrates with a functional periplasmic intermediate

TJ Smith, H Sondermann, GA O'Toole - Journal of Bacteriology, 2018 - Am Soc Microbiol
Bacteria have evolved several secretion strategies for polling and responding to
environmental flux and insult. Of these, the type 1 secretion system (T1SS) is known to …

A peptide-binding domain shared with an Antarctic bacterium facilitates Vibrio cholerae human cell binding and intestinal colonization

CJ Lloyd, S Guo, B Kinrade, H Zahiri… - Proceedings of the …, 2023 - National Acad Sciences
Vibrio cholerae, the causative agent of the disease cholera, is responsible for multiple
pandemics. V. cholerae binds to and colonizes the gastrointestinal tract within the human …

Engineered living materials based on adhesin-mediated trapping of programmable cells

S Guo, E Dubuc, Y Rave, M Verhagen… - ACS synthetic …, 2020 - ACS Publications
Engineered living materials have the potential for wide-ranging applications such as
biosensing and treatment of diseases. Programmable cells provide the functional basis for …

Metabolic interplay between Proteus mirabilis and Enterococcus faecalis facilitates polymicrobial biofilm formation and invasive disease

BC Hunt, V Brix, J Vath, LB Guterman, SM Taddei… - mBio, 2024 - journals.asm.org
Biofilms play an important role in the development and pathogenesis of catheter-associated
urinary tract infection (CAUTI). Proteus mirabilis and Enterococcus faecalis are common …

RTX adhesins are key bacterial surface megaproteins in the formation of biofilms

S Guo, TDR Vance, CA Stevens, I Voets… - Trends in microbiology, 2019 - cell.com
Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to
facilitate microbial adhesion. These large, multidomain proteins share a common …

Sugar-binding and split domain combinations in repeats-in-toxin adhesins from Vibrio cholerae and Aeromonas veronii mediate cell-surface recognition and …

M Sherik, R Eves, S Guo, CJ Lloyd, KE Klose… - Mbio, 2024 - Am Soc Microbiol
Many pathogenic Gram-negative bacteria use repeats-in-toxin adhesins for colonization and
biofilm formation. In the cholera agent Vibrio cholerae, flagellar-regulated hemagglutinin A …

Redefining the bacterial Type I protein secretion system

FJ Hodges, LT Von Vergel, AF Cunningham… - Advances in Microbial …, 2023 - Elsevier
Type I secretion systems (T1SS) are versatile molecular machines for protein transport
across the Gram-negative cell envelope. The archetypal Type I system mediates secretion of …

Structural basis of ligand selectivity by a bacterial Adhesin Lectin involved in multispecies biofilm formation

S Guo, TDR Vance, H Zahiri, R Eves, C Stevens… - MBio, 2021 - Am Soc Microbiol
Carbohydrate recognition by lectins governs critical host-microbe interactions. Mp PA14
(Marinomonas primoryensis PA14 domain) lectin is a domain of a 1.5-MDa adhesin …

Ice-Binding Proteins Associated with an Antarctic Cyanobacterium, Nostoc sp. HG1

JA Raymond, MG Janech… - Applied and …, 2021 - Am Soc Microbiol
Ice-binding proteins (IBPs) have been identified in numerous polar algae and bacteria, but
so far not in any cyanobacteria, despite the abundance of cyanobacteria in polar regions …