Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis
(ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression …

Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Neurodegenerative, neurodevelopmental and neuropsychiatric disorders are among the
greatest public health challenges, as many lack disease-modifying treatments. A major …

Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering
complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Neuronal intranuclear inclusion disease (NIID) is neurodegenerative disease characterized
by widespread inclusions. Despite the identification of GGC repeat expansion in 5'UTR of …

A large hexanucleotide (G 4 C 2) repeat expansion in the first intronic region of C9orf72 is
the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal …