Abstracts Background The number of studies measuring breakdown products of the
glycocalyx in plasma has increased rapidly during the past decade. The purpose of the …

Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

The endothelial glycocalyx (EG) as part of the endothelial surface layer (ESL) is an important
regulator of vascular function and homeostasis, including permeability, vascular tone …

Malaria caused by Plasmodium falciparum results in over 400,000 deaths annually,
predominantly affecting African children. In addition, non-falciparum species including vivax …

Cardiovascular instability and reduced oxygenation are regular perioperative critical events
associated with anesthesia requiring intervention in neonates and young infants. This …

The vascular endothelium is the interface between circulating blood and end organs and
thus has a critical role in preserving organ function. The endothelium is lined by a glycan …

Fluid therapy is a fundamental part of supportive therapy in critical care. However, it is also a
suspected risk for endothelial glycocalyx degradation which is associated with poor clinical …

Endothelial activation and microvascular dysfunction are key pathogenic processes in
severe malaria. We evaluated the early role of these processes in experimentally induced …

Several interventional strategies have been implemented in malaria endemic areas where
the burden is high, that include among others, intermittent preventive treatment (IPT), a tactic …

Degradation of the endothelial glycocalyx is associated with mortality in adult falciparum
malaria. However, its role in the pathogenesis of non-falciparum malaria is unknown. In …