Transcriptome view of a killer: African swine fever virus

G Cackett, M Sýkora, F Werner - Biochemical Society …, 2020 - portlandpress.com
African swine fever virus (ASFV) represents a severe threat to global agriculture with the
world's domestic pig population reduced by a quarter following recent outbreaks in Europe …

The African swine fever virus transcriptome

G Cackett, D Matelska, M Sýkora, R Portugal… - Journal of …, 2020 - Am Soc Microbiol
African swine fever virus (ASFV) causes hemorrhagic fever in domestic pigs, presenting the
biggest global threat to animal farming in recorded history. Despite the importance of ASFV …

Multisubunit RNA polymerases of jumbo bacteriophages

ML Sokolova, I Misovetc, K V. Severinov - Viruses, 2020 - mdpi.com
Prokaryotic viruses with DNA genome longer than 200 kb are collectively referred to as
“jumbo phages”. Some representatives of this phylogenetically diverse group encode two …

Structure of the recombinant RNA polymerase from African Swine Fever Virus

S Pilotto, M Sýkora, G Cackett, C Dulson… - Nature …, 2024 - nature.com
Abstract African Swine Fever Virus is a Nucleo-Cytoplasmic Large DNA Virus that causes an
incurable haemorrhagic fever in pigs with a high impact on global food security. ASFV …

The replication machinery of LUCA: common origin of DNA replication and transcription

EV Koonin, M Krupovic, S Ishino, Y Ishino - BMC biology, 2020 - Springer
Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs)
are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The …

The extended “two-barrel” polymerases superfamily: structure, function and evolution

L Sauguet - Journal of molecular biology, 2019 - Elsevier
Abstract DNA and RNA polymerases (DNAP and RNAP) play central roles in genome
replication, maintenance and repair, as well as in the expression of genes through their …

The evolutionary ecology of fungal killer phenotypes

TJ Travers-Cook, J Jokela… - Proceedings of the …, 2023 - royalsocietypublishing.org
Ecological interactions influence evolutionary dynamics by selecting upon fitness variation
within species. Antagonistic interactions often promote genetic and species diversity, despite …

Messenger RNAs of yeast virus-like elements contain non-templated 5′ Poly (A) leaders, and their expression is independent of eIF4E and Pab1

V Vopálenský, M Sýkora, T Mašek… - Frontiers in …, 2019 - frontiersin.org
We employed virus-like elements (VLEs) pGKL1, 2 from Kluyveromyces lactis as a model to
investigate the previously neglected transcriptome of the broader group of yeast cytoplasmic …

New Cytoplasmic Virus-Like Elements (VLEs) in the Yeast Debaryomyces hansenii

X Połomska, C Neuvéglise, J Zyzak, B Żarowska… - Toxins, 2021 - mdpi.com
Yeasts can have additional genetic information in the form of cytoplasmic linear dsDNA
molecules called virus-like elements (VLEs). Some of them encode killer toxins. The aim of …

A System to Explore the Adaptive Dynamics of Multicopy Plasmids: The Role of Copy Number and Mutation Rate in Evolutionary Outcomes

A Pisera, CC Liu - bioRxiv, 2024 - biorxiv.org
Multicopy plasmids are widespread in nature and compose a common strategy for
spreading beneficial traits across microbes. However, the role of plasmids in supporting the …