Background Up to 60% of melanoma patients develop melanoma brain metastases (MBM),
which traditionally have a poor diagnosis. Current treatment strategies include …

Stereotactic radiosurgery (SRS) is a mainstay treatment option for brain metastasis (BM).
While guidelines for SRS use have been outlined by professional societies, consideration of …

The diagnosis of brain metastases has historically been a dreaded, end-stage complication
of systemic disease. Additionally, with the increasing effectiveness of systemic therapies that …

Simple Summary Melanoma patients who failed anti-PD-1 therapy have limited therapeutic
options. Some studies suggested the efficacy of radiotherapy combined with anti-PD-1 …

Simple Summary The increasing use of targeted therapy (TT) has resulted in prolonged
disease control and survival in many metastatic cancers. In parallel, stereotactic …

Randomized controlled trials have failed to report any survival advantage for WBRT
combined with SRS in the management of brain metastases, despite the enhanced local …

Abstract Purpose of Review This review summarizes the current role of radiotherapy for the
treatment of cutaneous melanoma in the definitive, adjuvant, and palliative settings, and …

Background: Despite the profound effect that checkpoint inhibitors and BRAF/MEK inhibitors
have had on survival in patients with metastatic melanoma, treatment options remain limited …

Glioma is one of the most common malignant brain tumors with a high mortality rate and a
low chance of cure. Currently, the treatments for gliomas consist of surgery (usually the most …

Introduction: Cutaneous melanoma brain metastases (MBM) are a major cause of morbidity
and mortality. While cytotoxic agents, interferon, or interleukin-2, have been used with some …