Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

Proviral integration sitea for Moloney-murine leukemia virus (PIM) kinases are a family of
highly conserved serine/tyrosine kinases consisting of three members, PIM-1, PIM-2, and …

Chronic inflammation is frequently associated with myeloproliferative neoplasms (MPN), but
the role of inflammation in the pathogenesis of MPN remains unclear. Expression of the …

Small molecule inhibitors targeting JAK2 provide symptomatic benefits for myeloproliferative
neoplasm (MPN) patients and are among first‐line therapeutic agents. However, despite all …

Pim Kinases; Pim-1, Pim-2, and Pim-3, are a family of constitutively active serine/threonine
kinases, widely associated with cell survival, proliferation, and migration. Historically …

Bone marrow fibrosis represents an important structural change in the marrow that interferes
with some of its normal functions. The aetiopathogenesis of fibrosis is not well established …

Pancreatic cancer is one of the leading causes of cancer deaths, with pancreatic ductal
adenocarcinoma (PDAC) being the most common subtype. Advanced stage diagnosis of …

Primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET)
form the classical BCR-ABL1-negative myeloproliferative neoplasms (MPNs) that are driven …

Lay Summary We studied the effect and mechanism of ruxolitinib on ulcerative colitis. We
discovered that ruxolitinib administration significantly alleviated murine colitis by relieving …

Opinion statement Currently approved therapies for myelofibrosis (MF) consist of JAK
inhibitors, which produce meaningful improvements in spleen size and symptom burden but …