Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of
disability. Characterized by degradation of articular cartilage, synovial inflammation, and …

Skeletal tissue development and regeneration in mammals are intricate, multistep, and
highly regulated processes. Various signaling pathways have been implicated in the …

Bone is composed of dense and solid cortical bone and honeycomb-like trabecular bone.
Although cortical bone provides the majority of mechanical strength for a bone, there are few …

Notch1-4 receptors and their signaling pathways are expressed in almost all organ systems
and play a pivotal role in cell fate decision by coordinating cell proliferation, differentiation …

Background It is well-known that both macrophages and osteocytes are critical regulators of
osteogenesis and osteoclastogenesis, yet there is limited understanding of the macrophage …

Osteogenesis is an important developmental event that results in bone formation. Bone
forming cells or osteoblasts develop from mesenchymal stem cells (MSCs) through a highly …

Notch is a cell–cell signaling pathway that is involved in a host of activities including
development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent …

The homeostasis of osteochondral tissue is tightly controlled by articular cartilage
chondrocytes and underlying subchondral bone osteoblasts via different internal and …

Not much is known about the time course of mineralization in newly formed bone from
healthy individuals nor in patients with bone disease. To investigate the early phase of …

Motivation The molecular processes regulating molluscan shell production remain relatively
uncharacterized, despite the clear evolutionary and societal importance of biomineralization …