In order to expand the prospects of developing novel antidepressants for treatment-resistant
populations, animal models should incorporate not only various stress-induced behavioural …

The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …

Major depressive disorder (MDD) is one of the leading causes of years lived with disability
and contributor to the burden of disease worldwide. The incidence of MDD has increased …

Recent studies have implicated the hypocretin/orexinergic system in reward-seeking
behavior. Almorexant, a dual orexin/hypocretin R1 and R2 receptor antagonist, has proven …

The dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2), and
dopamine transporter (DAT) densities were measured in 11 aged human brains (aged 77 …

Major depressive disorder is a growing and poorly understood pathology. Due to technical
and ethical limitations, a significant proportion of the research on depressive disorders …

Previous studies have shown that the Wistar-Kyoto (WKY) rat strain may be a genetic model
of depression when their behaviors are compared to Sprague-Dawley (SD) or Wistar (WIS) …

The striatum with a number of dopamine containing neurons, receiving projections from the
substantia nigra and ventral tegmental area; plays a critical role in neurodegenerative …

Stressful experiences during adolescence can alter the trajectory of neural development and
contribute to psychiatric disorders in adulthood. We previously demonstrated that adolescent …

Rationale Although numerous studies have suggested that pharmacological alteration of the
dopamine (DA) system modulates reward discounting, these studies have produced …