Obesity is associated with chronic inflammation, which contributes to insulin resistance and
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …

Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

摘要背景鸢尾素(irisin) 是一种在小鼠和人类体内新发现的肌细胞因子(myokine).
很多研究已经报道了2 型糖尿病患者体内的鸢尾素水平. 各研究中报告的鸢尾素水平的巨大差异 …

White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and
capable of establishing ways of communicating and influencing multiple metabolic …

Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to
be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …