Microglial efferocytosis: diving into the Alzheimer's disease gene pool
Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …
Non-coding driver mutations in human cancer
Tumour formation involves random mutagenic events and positive evolutionary selection
acting on a subset of such events, referred to as driver mutations. A decade of careful …
acting on a subset of such events, referred to as driver mutations. A decade of careful …
[HTML][HTML] Multi-omics single-cell data integration and regulatory inference with graph-linked embedding
ZJ Cao, G Gao - Nature Biotechnology, 2022 - nature.com
Despite the emergence of experimental methods for simultaneous measurement of multiple
omics modalities in single cells, most single-cell datasets include only one modality. A major …
omics modalities in single cells, most single-cell datasets include only one modality. A major …
[HTML][HTML] Cohesin and CTCF control the dynamics of chromosome folding
In mammals, interactions between sequences within topologically associating domains
enable control of gene expression across large genomic distances. Yet it is unknown how …
enable control of gene expression across large genomic distances. Yet it is unknown how …
[PDF][PDF] A single-cell atlas of chromatin accessibility in the human genome
Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity
Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate
target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking …
target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking …
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics
Abstract Open Targets Genetics (https://genetics. opentargets. org) is an open-access
integrative resource that aggregates human GWAS and functional genomics data including …
integrative resource that aggregates human GWAS and functional genomics data including …
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
Genome-wide association studies (GWASs) have identified many variants associated with
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
Transcriptional coupling of distant regulatory genes in living embryos
The prevailing view of metazoan gene regulation is that individual genes are independently
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …
Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue
Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …