Niosomes (the nonionic surfactant vesicles), considered as novel drug delivery systems, can
improve the solubility and stability of natural pharmaceutical molecules. They are …

During the last decades, numerous basic and clinical studies have been conducted to
assess the delivery efficiency of therapeutic agents into the brain and spinal cord …

Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to
its accumulation in typical protein aggregates in the brain. However, it is still unclear how it …

Abstract Context Coriandrum sativum L.(Apiaceae)(coriander) is an herb grown throughout
the world as a culinary, medicinal or essential crop. In traditional medicine, it is used for the …

Neuroinflammation plays an important role in the pathophysiology of surgical brain injury
(SBI). Phosphoinositide 3-kinase gamma (PI3Kγ), predominately expressed in immune and …

Quinolinic acid (QA) is a NMDA receptor agonist implicated in pathological conditions, such
as neurodegenerative diseases and epilepsy. Time-course responses of different brain …

Brain diseases are becoming a more and more serious threat to human health. Many critical
properties of the transport mechanisms of drugs in live brains remain poorly understood. In …

Rationale: Recent studies have demonstrated the direct connections between the skull bone
marrow, meninges, and brain. In an effort to explore these connections for the purpose of …

Heme-degradation after erythrocyte lysis plays an important role in the pathophysiology of
intracerebral hemorrhage. Low-density lipoprotein receptor-related protein-1 is a receptor …

Nanotheranostics constitute a novel drug delivery system approach to improving systemic,
brain-targeted delivery of diagnostic imaging agents and pharmacological moieties in one …