Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …