Telomerase activity is dependent on the expression of 2 main core component genes,
hTERT, which encodes the catalytic component and hTR (also called TERC), which …

Telomerase and telomeres are attractive targets for anticancer therapy. This is supported by
the fact that the majority of human cancers express the enzyme telomerase which is …

A number of different approaches have been developed to inhibit telomerase activity in
human cancer cells. Different components and types of inhibitors targeting various …

The length of the telomeres is maintained with the help of the enzyme telomerase
constituting of two components, namely, a core reverse transcriptase protein (hTERT) and …

The human adult mesenchymal stem cell (hMSC) does not express telomerase and has
been shown to be the target for neoplastic transformation after transduction with hTERT …

Although scientific advances have recognised the prognostic power of telomerase activity in
different cancers, as yet there has been no investigation regarding the expression variation …

Rapid advances in our understanding of the molecular basis of cancer development and
progression over the past three decades have led to the design of new potential cancer …

Based on the finding that telomerase is reactivated solely in cancer cells, the human
telomerase reverse transcriptase (hTERT) promoter has recently been used to target cancer …

The human telomerase reverse transcriptase (hTERT) is expressed in more than 85% of
tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor …

Background Telomerase is widely expressed in most human cancers, but is almost
undetectable in normal somatic cells and is therefore a potential drug target. Using the …