Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is
the ability for continuous cell divisions that almost universally correlates with the stabilization …

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course
ranges from spontaneous tumor regression to fatal progression. To investigate the molecular …

Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

Correspondence to S. Bacchetti. research in this field may render the information rapidly
outdated, we hope that the present survey of over 3500 tumour and control samples will aid …

Neuroblastomas are characterized by heterogeneous clinical behavior, from spontaneous
regression or differentiation into a benign ganglioneuroma, to relentless progression despite …

Neuroblastoma is a tumour derived from primitive cells of the sympathetic nervous system
and is the most common solid tumour in childhood. Interestingly, most infants experience …

Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the
ends from damage and rearrangements. Telomere repeats are synthesized by telomerase, a …

Telomerase is a ribonucleoprotein that synthesizes telomere repeats onto chromosome
ends and is involved in maintaining telomere length in germline tissues and in immortal and …