Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …

Knee osteoarthritis (KOA) is one of the most common degenerative diseases, and its core
feature is the degeneration and damage of articular cartilage. The cartilage degeneration of …

Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis
(OA), a prevalent progressive degenerative joint disease that causes debilitating pain …

The engineering of fully functional, biological‐like tissues requires biomaterials to direct
cellular events to a near‐native, 3D niche extent. Natural biomaterials are generally seen as …

Objective Osteoarthritis (OA) is a complex disease involving contributions from both local
joint tissues and systemic sources. Patient characteristics, encompassing sociodemographic …

Mechanical stimulation appears to play a key role in cartilage homeostasis maintenance, but
it can also contribute to osteoarthritis (OA) pathogenesis. Accumulating evidence suggests …

Bones and articular cartilage are important load-bearing tissues. The fluid flow inside the
bone cells and cell interaction with the extracellular matrix serve as the mechanical cues for …

Purpose: An underlying cause of osteoarthritis (OA) is the inability of chondrocytes to
maintain homeostasis in response to changing stress conditions. The purpose of this article …

Recent research effort in biomaterial development has largely focused on engineering bio-
instructive materials to stimulate specific cell signaling. Assessing the biological …

In living organisms, cells sense mechanical forces (shearing, tensile, and compressive) and
respond to those physical cues through a process called mechanotransduction. This …