The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

Immunological memory is a composite of lasting antibody titers maintained by plasma cells
in conjunction with memory T and B cells. Memory B cells are a critical reservoir for plasma …

Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …

High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …

B cells are increasingly recognized as playing an important role in the ongoing control of
hepatitis B virus (HBV). The development of antibodies against the viral surface antigen …

B cell subsets expressing the transcription factor T-bet are associated with humoral immune
responses and autoimmunity. Here, we examined the anatomic distribution, clonal …

Innate and adaptive immune responses decline with age, leading to greater susceptibility to
infectious diseases and reduced responses to vaccines. Diseases are more severe in old …

Immunological memory is a remarkable phenomenon in which survival of an initial infection
by a pathogen leads to life-long protection from disease upon subsequent exposure to that …

Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …

Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …