Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

There is increasing evidence that autism spectrum disorders (ASDs) can arise from rare
highly penetrant mutations and genomic imbalances. The rare nature of these variants, and …

Balanced chromosomal abnormalities (BCAs) represent a relatively untapped reservoir of
single-gene disruptions in neurodevelopmental disorders (NDDs). We sequenced BCAs in …

The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …

Brown adipose tissue (BAT) dissipates chemical energy in the form of heat as a defence
against hypothermia and obesity. Current evidence indicates that brown adipocytes arise …

Mutations in more than 450 different genes have been associated with intellectual disability
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …

Individuals with lower socio-economic status (SES) are at increased risk of physical and
mental illnesses and tend to die at an earlier age [1–3]. Explanations for the association …

A clinically recognizable 9q subtelomeric deletion syndrome has recently been established.
Common features seen in these patients are severe mental retardation, hypotonia …

Cancer is perceived as a heterogeneous group of diseases that is characterized by aberrant
patterns of gene expression. In the last decade, an increasing amount of data has pointed to …