The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer

S Mohan, MA Hakami, HG Dailah, A Khalid… - … -Research and Practice, 2024 - Elsevier
Noncoding ribonucleic acids (ncRNAs) have surfaced as essential orchestrators within the
intricate system of neoplastic biology. Specifically, the epidermal growth factor receptor …

Integrating Multi-Omics analysis for enhanced diagnosis and treatment of glioblastoma: A comprehensive Data-Driven approach

A Barzegar Behrooz, H Latifi-Navid, SC da Silva Rosa… - Cancers, 2023 - mdpi.com
Simple Summary The most prevalent and lethal primary brain tumor, glioblastoma
multiforme (GBM), exhibits fast growth and widespread invasion and has a poor prognosis …

[HTML][HTML] Nuclear transport surveillance of p53 by nuclear pores in glioblastoma

DK Ikliptikawati, N Hirai, K Makiyama, H Sabit… - Cell Reports, 2023 - cell.com
Nuclear pore complexes (NPCs) are the central apparatus of nucleocytoplasmic transport.
Disease-specific alterations of NPCs contribute to the pathogenesis of many cancers; …

Therapeutic Implications of Targeting YY1 in Glioblastoma

I Navasardyan, A Zaravinos, B Bonavida - Cancers, 2024 - mdpi.com
Simple Summary This report explores the multifaceted role of the transcription factor Yin
Yang 1 (YY1), which is overexpressed in many cancers and involved in the regulation of …

Mechanistic insights into super-enhancer-driven genes as prognostic signatures in patients with glioblastoma

Y Chen, Y Pan, H Gao, Y Yi, S Qin, F Ma… - Journal of Cancer …, 2023 - Springer
Background Glioblastoma (GBM) is one of the most common malignant brain tumors in
adults and is characterized by high aggressiveness and rapid progression, poor treatment …

Chlorpromazine overcomes temozolomide resistance in glioblastoma by inhibiting Cx43 and essential DNA repair pathways

P Matarrese, M Signore, B Ascione, G Fanelli… - Journal of Translational …, 2024 - Springer
Background In the fight against GBM, drug repurposing emerges as a viable and time-
saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic …

[HTML][HTML] Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity

J Li, Y Tang, G Lu, Q Liu, Y Guo, J Wang, M Xiao… - Journal of Advanced …, 2024 - Elsevier
Introduction Lipid metabolism disorders have been confirmed to be closely related to kidney
injury caused by adriamycin (ADR) and obesity, respectively. However, it has not been …

Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma

T Guo, C Wu, J Zhang, J Yu, G Li, H Jiang… - Cell Communication and …, 2023 - Springer
Background Glioblastoma multiforme (GBM) is a devastating disease that lacks effective
drugs for targeted therapy. Previously, we found that the third-generation epidermal growth …

TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA‐PKcs

C Xu, G Chen, B Yu, B Sun, Y Zhang… - Advanced …, 2024 - Wiley Online Library
The factors driving glioma progression remain poorly understood. Here, the epigenetic
regulator TRIM24 is identified as a driver of glioma progression, where TRIM24 …

Comprehensive analysis reveals epithelial growth factor receptor as a potential diagnostic biomarker in glioblastoma multiforme

A Makawi, SA Khalafallah, IM Faris, M Alfaki - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Glioblastoma multiforme (GBM), a highly aggressive tumor of the central nervous system, is
the most common malignant brain tumor and poses a significant risk to life. GBM patients …