Evolution and diversity of immune responses during acute HIV infection

SW Kazer, BD Walker, AK Shalek - Immunity, 2020 - cell.com
Understanding the earliest immune responses following HIV infection is critical to inform
future vaccines and therapeutics. Here, we review recent prospective human studies in at …

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

DJ Colby, L Trautmann, S Pinyakorn, L Leyre… - Nature medicine, 2018 - nature.com
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might
minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after …

Immunologic characteristics of HIV‐infected individuals who make broadly neutralizing antibodies

P Borrow, MA Moody - Immunological reviews, 2017 - Wiley Online Library
Induction of broadly neutralizing antibodies (bnAbs) capable of inhibiting infection with
diverse variants of human immunodeficiency virus type 1 (HIV‐1) is a key, as‐yet …

SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung

NK Routhu, N Cheedarla, VS Bollimpelli… - Nature …, 2021 - nature.com
There is a great need for the development of vaccines that induce potent and long-lasting
protective immunity against SARS-CoV-2. Multimeric display of the antigen combined with …

Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses

R Muir, T Metcalf, S Fourati, Y Bartsch… - PLoS neglected …, 2023 - journals.plos.org
Schistosomiasis is a disease caused by parasitic flatworms of the Schistosoma spp., and is
increasingly recognized to alter the immune system, and the potential to respond to …

Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection

JL Mitchell, J Pollara, K Dietze… - The Journal of …, 2022 - Am Soc Clin Investig
Early initiation of antiretroviral therapy (ART) in acute HIV infection (AHI) is effective at
limiting seeding of the HIV viral reservoir, but little is known about how the resultant …

Human antiviral B cell responses: Emerging lessons from hepatitis B and COVID‐19

AR Burton, MK Maini - Immunological Reviews, 2021 - Wiley Online Library
Humoral immunity is a critical component of the coordinated response required to resolve
viral infections and mediate protection following pathogen clearance or vaccination. A better …

Peripheral T follicular helper cells make a difference in HIV reservoir size between elite controllers and patients on successful cART

M García, M Górgolas, A Cabello, V Estrada… - Scientific Reports, 2017 - nature.com
HIV latency is the main barrier to HIV eradication. Peripheral T follicular helper (pTfh) cells
have a prominent role in HIV persistence. Herein, we analyzed the HIV reservoir size within …

[HTML][HTML] A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants

S Qin, H Huang, W Xiao, K Chen, X He, X Tang… - … Pharmaceutica Sinica B, 2023 - Elsevier
There are currently approximately 4000 mutations in the SARS-CoV-2 S protein gene and
emerging SARS-CoV-2 variants continue to spread rapidly worldwide. Universal vaccines …

CD4 T follicular helper and regulatory cell dynamics and function in HIV infection

B Miles, SM Miller, E Connick - Frontiers in immunology, 2016 - frontiersin.org
T follicular helper cells (TFH) are a specialized subset of CD4 T cells that reside in B cell
follicles and promote B cell maturation into plasma cells and long-lived memory B cells …