Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

Evidence demonstrates that chronic caffeine exposure, primarily through consumption of
coffee or tea, leads to increased alertness and anxiety. Preclinical and clinical studies …

Alcoholism is a serious public health concern that is characterized by the development of
tolerance to alcohol's effects, increased consumption, loss of control over drinking and the …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate
transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent …

Dysregulation of glutamate homeostasis is a well-established core feature of
neuropsychiatric disorders. Extracellular glutamate concentration is regulated by glutamate …

The gut microbiome modulates neurochemical function and behavior and has been
implicated in numerous central nervous system (CNS) diseases, including developmental …

Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in
alterations that perpetuate alcohol intake and cued relapse. Studies show that brain …