Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Bacterial secondary metabolites are a major source of antibiotics and other bioactive
compounds. In microbial communities, these molecules can mediate interspecies …

The anthracyclines are a family of natural products isolated from soil bacteria with over 2000
chemical representatives. Since their discovery seventy years ago by Waksman and co …

The anthracyclines are structurally diverse anticancer natural products that bind to DNA and
poison the topoisomerase II–DNA complex in cancer cells. Rational modifications in the …

A wide variety of bacteria, fungi and plants can produce bioactive secondary metabolites,
which are often referred to as natural products. With the rapid development of DNA …

Daptomycin (DAP) is a novel microbial lipopeptide antibiotic synthesized by the DAP
biosynthetic gene cluster dpt of Streptomyces roseosporus (S. roseosporus). DptP gene …

A number of new developments in molecular biology, metabolic engineering, chemical
analytics and DNA sequencing have led to renewed interest in novel bioactive natural …

Gram-negative unicellular myxobacteria, along with their multicellular lifestyle and
biologically active specialized metabolites, are known for the predatory interactions with …

With a largely unexplored biodiversity, fungi are an untapped source of novel compounds,
many of which exhibit biological activity. Some of the already known molecules, such as …

Daptomycin (DAP) is a novel microbial lipopeptide antibiotic synthesized by the DAP
biosynthetic gene cluster dpt of Streptomyces roseosporus (S. roseosporus). DptP gene …