Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …
factors and comprise common noncommunicable diseases, including allergies …
Philosophy of psychiatry: theoretical advances and clinical implications
DJ Stein, K Nielsen, A Hartford… - World …, 2024 - Wiley Online Library
Work at the intersection of philosophy and psychiatry has an extensive and influential
history, and has received increased attention recently, with the emergence of professional …
history, and has received increased attention recently, with the emergence of professional …
Neurobiological basis of stress resilience
EJ Nestler, SJ Russo - Neuron, 2024 - cell.com
A majority of humans faced with severe stress maintain normal physiological and behavioral
function, a process referred to as resilience. Such stress resilience has been modeled in …
function, a process referred to as resilience. Such stress resilience has been modeled in …
[HTML][HTML] Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …
[HTML][HTML] Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain
Recent findings link cognitive impairment and inflammatory-immune dysregulation in
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …
[HTML][HTML] Geographical variation in treated psychotic and other mental disorders in Finland by region and urbanicity
Abstract Purpose In Finland, prevalence of schizophrenia is higher in the eastern and
northern regions and co-occurs with the distribution of schizophrenia polygenic risk scores …
northern regions and co-occurs with the distribution of schizophrenia polygenic risk scores …
Did the human genome project affect research on Schizophrenia?
EF Torrey - Psychiatry Research, 2024 - Elsevier
Abstract The Human Genome Project was undertaken primarily to discover genetic causes
and better treatments for human diseases. Schizophrenia was targeted since three of the …
and better treatments for human diseases. Schizophrenia was targeted since three of the …
Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data
JA Sanchez-Ruiz, BJ Coombes, VM Pazdernik… - Molecular …, 2024 - nature.com
Bipolar disorder is a chronic and complex polygenic disease with high rates of comorbidity.
However, the independent contribution of either diagnosis or genetic risk of bipolar disorder …
However, the independent contribution of either diagnosis or genetic risk of bipolar disorder …
Dimensions of psychopathology associated with psychotic-like experiences: Findings from the network analysis in a nonclinical sample
M Rejek, B Misiak - European Psychiatry, 2023 - cambridge.org
BackgroundPsychotic-like experiences (PLEs) are associated with a variety of
psychopathological symptoms. However, it remains unknown which dimensions of …
psychopathological symptoms. However, it remains unknown which dimensions of …
Mutational landscape of risk variants in comorbid depression and obesity: a next-generation sequencing approach
Major depression (MD) and obesity are complex genetic disorders that are frequently
comorbid. However, the study of both diseases concurrently remains poorly addressed and …
comorbid. However, the study of both diseases concurrently remains poorly addressed and …