Chronic pain exerts an enormous personal and economic burden, affecting more than 30%
of people worldwide according to some studies. Unlike acute pain, which carries survival …

Analysis and interpretation of studies on cognitive and affective dysregulation often draw
upon the network paradigm, especially the Triple Network Model, which consists of the …

Chronic pain is not simply a temporal continuum of acute pain. Studies on functional
plasticity in neural circuits of pain have provided mechanistic insights and linked various …

Background It is nearly impossible to overestimate the burden of chronic pain, which is
associated with enormous personal and socioeconomic costs. Chronic pain is the leading …

Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to
date has focused on the knee, with results often extrapolated to the hip, and this extends to …

Chronic pain is a common public health problem that has a detrimental impact on patient
health, quality of life (QoL), and function, and poses a substantial socioeconomic burden …

Pain and stress share significant conceptual and physiological overlaps. Both phenomena
challenge the body's homeostasis and necessitate decision-making to help animals adapt to …

Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk
for developing chronic pain. Within this context, we revisit the concepts for nociception, acute …

An emerging technique in chronic pain research is MRI, which has led to the understanding
that chronic pain patients display brain structure and function alterations. Many of these …

Tinnitus and chronic pain are sensory–perceptual disorders associated with negative affect
and high impact on well-being and behavior. It is now becoming increasingly clear that …