The last fifty years, ophthalmic drug delivery research has made much progress, challenging
scientists about the advantages and limitations of this drug delivery approach. Topical eye …

Highlights•A guideline for the development of ophthalmic in situ gelling systems is
proposed.•Gelation, gelation kinetics and rheological characterization methods are …

Abstract α-Lipoic acid (ALA) is a powerful antioxidant valuable for prevention and treatment
of ophthalmic complications such as diabetic keratopathy and retinopathy. The aim of this …

Nearly 20% of people affected by the herpes simplex virus (HSV) suffer from vision
problems. The virus can infect all layers of the cornea or cause inflammatory diseases of the …

The aim of this work was to develop niosomes for the ocular delivery of epalrestat, a drug
that inhibits the polyol pathway and protects diabetic eyes from damage linked to sorbitol …

Oral administration of cholesterol-lowering statins, HMG-CoA reductase inhibitors, is
associated with beneficial effects on eye conditions. This work aims to design contact lenses …

The pharmaceutical industry has entered in a new era, as there is a growing interest in
increasing the quality standards of dosage forms, through the implementation of more …

A variety of ocular diseases are caused by viruses, and most treatments rely on the use of
systemic formulations and eye drops. The efficient ocular barriers that oppose antiviral drug …

Ophthalmic diseases can result in permanent vision loss and blindness. Convenient topical
and systemic treatments are preferred to address these sight-threatening conditions …

The rate of release of an active pharmaceutical ingredient (API) from a topical semisolid
dosage form can be influenced by its physical and structural properties. An In Vitro Release …