Adaptive evolution is shaped by the interaction of population genetics, natural selection and
underlying network and biochemical constraints. Variation created by mutation, the raw …

Dietary restriction (DR) under laboratory conditions generally extends life span and delays
ageing across species as diverse as yeast, nematode worms, flies and mice, and is …

Searching for Darwinian selection in natural populations has been the focus of a multitude of
studies over the last decades. Here we present the 1000 Genomes Selection Browser 1.0 …

An animal's survival strongly depends on its ability to maintain homeostasis in response to
the changing quality of its external and internal environment. This is achieved through …

Embryonic development is one of the most sensitive and critical stages when maternal
effects may influence the offspring's phenotype. In birds and other oviparous species …

Humans living at high altitude (≥ 2,500 meters above sea level) have acquired unique
abilities to survive the associated extreme environmental conditions, including hypoxia, cold …

Advances in high throughput sequencing technologies have created a gap between data
production and functional data analysis. Indeed, phenotypes result from interactions …

Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that
determine adaptability, however, remain poorly understood. Genes function in the context of …

The insulin/insulin-like signaling and target of rapamycin (IIS/TOR) network regulates
lifespan and reproduction, as well as metabolic diseases, cancer, and aging. Despite its vital …

Genes show a bewildering variation in their patterns of molecular evolution, as a result of the
action of different levels and types of selective forces. The factors underlying this variation …