Metabolic reprogramming and epigenetic modifications on the path to cancer
L Sun, H Zhang, P Gao - Protein & cell, 2022 - academic.oup.com
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes
JP Etchegaray, R Mostoslavsky - Molecular cell, 2016 - cell.com
The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …
networks that establish a coherent molecular program that is in tune with nutritional …
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are
mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate …
mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate …
What a difference a hydroxyl makes: mutant IDH,(R)-2-hydroxyglutarate, and cancer
JA Losman, WG Kaelin - Genes & development, 2013 - genesdev.cshlp.org
Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human …
The recent identification of IDH mutations in gliomas and several other cancers suggests
that this pathway is involved in oncogenesis; however effector functions are complex and yet …
that this pathway is involved in oncogenesis; however effector functions are complex and yet …
Lactate dehydrogenase A in cancer: a promising target for diagnosis and therapy
P Miao, S Sheng, X Sun, J Liu, G Huang - IUBMB life, 2013 - Wiley Online Library
One of the principal biochemical characteristics of malignant cells compared to normal cells
is a metabolic switch from oxidative phosphorylation to increased glycolysis, even under …
is a metabolic switch from oxidative phosphorylation to increased glycolysis, even under …
IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives
Genes encoding for isocitrate dehydrogenases 1 and 2, IDH1 and IDH2, are frequently
mutated in multiple types of human cancer. Mutations targeting IDH1 and IDH2 result in …
mutated in multiple types of human cancer. Mutations targeting IDH1 and IDH2 result in …
Role of TET enzymes in DNA methylation, development, and cancer
KD Rasmussen, K Helin - Genes & development, 2016 - genesdev.cshlp.org
The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …
expression, and DNA methylation abnormalities are often observed in diseases. The ten …
Regulation of succinate dehydrogenase and role of succinate in cancer
E Dalla Pozza, I Dando, R Pacchiana, E Liboi… - Seminars in cell & …, 2020 - Elsevier
Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme
with the unique property to participate in both the citric acid cycle and the electron transport …
with the unique property to participate in both the citric acid cycle and the electron transport …
Nutrient sensing, metabolism, and cell growth control
Cell growth is regulated by coordination of both extracellular nutrients and intracellular
metabolite concentrations. AMP-activated kinase and mammalian target of rapamycin …
metabolite concentrations. AMP-activated kinase and mammalian target of rapamycin …