Monalizumab: inhibiting the novel immune checkpoint NKG2A
T Van Hall, P André, A Horowitz, DF Ruan… - … for immunotherapy of …, 2019 - Springer
The implementation of immune checkpoint inhibitors to the oncology clinic signified a new
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …
A genomic perspective on HLA evolution
Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer
ML Burr, CE Sparbier, KL Chan, YC Chan… - Cancer cell, 2019 - cell.com
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …
The dual role of HLA-C in tolerance and immunity at the maternal-fetal interface
H Papúchová, TB Meissner, Q Li… - Frontiers in …, 2019 - frontiersin.org
To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens
and remain competent to respond to infections both systemically and in placental tissues …
and remain competent to respond to infections both systemically and in placental tissues …
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
Long Noncoding RNA HCP5, a Hybrid HLA Class I Endogenous Retroviral Gene: Structure, Expression, and Disease Associations
JK Kulski - Cells, 2019 - mdpi.com
The HCP5 RNA gene (NCBI ID: 10866) is located centromeric of the HLA-B gene and
between the MICA and MICB genes within the major histocompatibility complex (MHC) class …
between the MICA and MICB genes within the major histocompatibility complex (MHC) class …
Factors affecting HLA expression: A review
BS Carey, KV Poulton, A Poles - International journal of …, 2019 - Wiley Online Library
The detection and semiquantitative measurement of circulating human leucocyte antigen
(HLA)‐specific antibodies is essential for the management of patients before and after …
(HLA)‐specific antibodies is essential for the management of patients before and after …
Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression
Human leukocyte antigen (HLA) class I and II loci are essential elements of innate and
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …
Expression estimation and eQTL mapping for HLA genes with a personalized pipeline
The HLA (Human Leukocyte Antigens) genes are well-documented targets of balancing
selection, and variation at these loci is associated with many disease phenotypes. Variation …
selection, and variation at these loci is associated with many disease phenotypes. Variation …
Capturing differential allele-level expression and genotypes of all classical HLA loci and haplotypes by a new capture RNA-seq method
F Yamamoto, S Suzuki, A Mizutani… - Frontiers in …, 2020 - frontiersin.org
The highly polymorphic human major histocompatibility complex (MHC) also known as the
human leukocyte antigen (HLA) encodes class I and II genes that are the cornerstone of the …
human leukocyte antigen (HLA) encodes class I and II genes that are the cornerstone of the …