Colorectal cancer (CRC) is a major health concern with multifactorial pathophysiology
representing intense therapeutic challenges. It is well known that deregulation of …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Abstract miR‐138‐5p has been identified as a novel cancer‐related miRNA molecule in a
variety of malignancies. However, the functions and mechanisms underlying miR‐138‐5p in …

Background The immunosuppressive microenvironment is closely related to tumorigenesis
and cancer development, including colorectal cancer (CRC). The aim of the current study …

Background Transient receptor potential channels (TRPC) play critical regulatory functions
in cancer occurrence and progression. However, knowledge on its role in colorectal cancer …

Drug resistance greatly limits the therapeutic efficacy of treatment of non-small cell lung
cancer (NSCLC). One of the important factors is the dysfunction of tumor suppressor p53 …

Genome-wide association studies (GWAS) are observational studies of a large set of genetic
variants in an individual's sample in order to find if any of these variants are linked to a …

Colorectal cancer is a significant public health concern. As a multistage and multifactorial
disease, environmental and genetic factors interact at each stage of the process, and an …

PGC1α, a central player in mitochondrial biology, holds a complex role in the metabolic
shifts seen in cancer cells. While its dysregulation is common across major cancers, its …

Obesity is well accepted as crucial risk factor that plays a critical role in the initiation and
progression of colorectal cancer (CRC). More specifically, visceral adipose tissue (VAT) in …