Clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing
has begun to transform the treatment landscape of genetic diseases. The history of the …

Due to the proliferation of genetic testing, pathogenic germline variants predisposing to
hereditary hematological malignancy syndrome (HHMS) have been identified in an …

Although numerous barriers for clinical germline cancer predisposition testing exist, the
increasing recognition of deleterious germline DNA variants contributing to myeloid …

Genomic advancements have yielded pivotal insights into hematological neoplasms,
particularly concerning germline predisposition mutations. Following the WHO 2016 …

Expedited evaluation of hereditary hematopoietic malignancies in the setting of stem cell
transplantation - PMC Skip to main content Here's how you know Official websites use .gov A …

Patients aged 50 or above diagnosed with myeloid neoplasms (MNs) are typically not
candidates for germline testing. However, approximately 8% carry pathogenic germline …

Clinical use of gene panel testing for hematopoietic neoplasms in areas, such as diagnosis,
prognosis prediction, and exploration of treatment options, has increased in recent years …

According to the 2016 World Health Organization classification, a germline DEAD‐box
helicase 41 gene (DDX41) mutation with myeloid neoplasms has been newly classified. The …

While intensive investigations unveiled a strong genotype–phenotype relationship, the
optimal therapeutic approach and long-term outcome are undefined. There is an urgent …