Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas
R Onciul, FM Brehar, C Toader… - Current Issues in …, 2024 - mdpi.com
Gliomas constitute a diverse and complex array of tumors within the central nervous system
(CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic …
(CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic …
“Reductive stress” the overlooked side of cellular redox modulation in cancer: opportunity for design of next generation redox chemotherapeutics
A Kunwar, J Aishwarya - Free Radical Research, 2024 - Taylor & Francis
The last three decades of redox biology research have been dominated by the term"
oxidative stress" since it was first coined by Helmut Sies to represent a form of cellular redox …
oxidative stress" since it was first coined by Helmut Sies to represent a form of cellular redox …
Exogenous substrates prevent the decline in the cellular ATP content of primary rat astrocytes during glucose deprivation
AR Harders, P Spellerberg, R Dringen - Neurochemical Research, 2024 - Springer
Brain astrocytes are well known for their broad metabolic potential. After glucose
deprivation, cultured primary astrocytes maintain a high cellular ATP content for many hours …
deprivation, cultured primary astrocytes maintain a high cellular ATP content for many hours …
ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer
Y Wang, X Gan, X Cheng, Y Jia, G Wang… - Clinical and …, 2024 - Wiley Online Library
Background Although it is traditionally believed that ATP binding cassette subfamily C
member 2 (ABCC2) is a multidrug resistance‐associated protein correlated with a worse …
member 2 (ABCC2) is a multidrug resistance‐associated protein correlated with a worse …
A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma
Glioma cells hijack developmental programs to control cell state. Here, we uncover a glioma
cell state-specific metabolic liability that can be therapeutically targeted. To model cell …
cell state-specific metabolic liability that can be therapeutically targeted. To model cell …
[HTML][HTML] Inhibition of LDHB suppresses the metastatic potential of lung cancer by reducing mitochondrial GSH catabolism
H Ge, F Malsiu, Y Gao, T Losmanova, F Blank, J Ott… - Cancer Letters, 2025 - Elsevier
Metastasis, the leading cause of cancer death, is closely linked to lactate metabolism. Our
study aimed to investigate the role of lactate dehydrogenase B (LDHB), which mainly …
study aimed to investigate the role of lactate dehydrogenase B (LDHB), which mainly …