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With their power to shape animal morphology, few genes have captured the imagination of
biologists as the evolutionarily conserved members of the Hox clusters have done. Recent …

Background In patients with acute myeloid leukemia (AML), the presence or absence of
recurrent cytogenetic aberrations is used to identify the appropriate therapy. However, the …

Chromosomal translocations in the human acute leukemias rearrange the regulatory and
coding regions of a variety of transcription factor genes. The resultant protein products can …

Many cancers seem to depend on a small population of'cancer stem cells' for their continued
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be …

Abstract Hoxa9, Meis1 and Pbx1 encode homeodomaincontaining proteins implicated in
leukemic transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have …

Hox transcription factors have emerged as important regulators of primitive hematopoietic
cell proliferation and differentiation. In particular, HOXB4 appears to be a strong positive …

Gene expression analyses, gene targeting experiments and retroviral overexpression
studies in the murine bone marrow transplantation model have provided strong correlative …

Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin
(NPMc+ AML) accounts for about one-third of adult AML and shows distinct features …

Hox genes encode homeodomain-containing transcription factors that pattern the body axes
of animal embryos. It is well established that the exquisite DNA-binding specificity that …