The overuse and inappropriate use of antibiotics to treat bacterial infections has led to the
development of multiple drug resistant strains. Biofilm is a complex microorganism …

Compounds incorporating guanidine moieties constitute a versatile class of biologically
interesting molecules with a wide array of applications. As such, guanidines have been …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

A perilous increase in the number of bacterial infections has led to developing throngs of
antibiotics for increasing the quality and expectancy of life. Pseudomonas aeruginosa is …

The rapid growth of antimicrobial resistance against several frontline antibiotics has
encouraged scientists worldwide to develop new alternatives with unique mechanisms of …

Excessive use of antibiotics accelerates the development and spread of drug-resistant
strains, which is a huge challenge for the field of medical health worldwide. Quaternary …

In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl
anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short …

This review identifies the ways in which tethered bilayer lipid membranes (tBLMs) can be
used for the identification of the actions of antimicrobials against lipid bilayers. Much of the …

We report on the design, synthesis, and properties of innovative, planar, π-conjugated
compounds in which a thiophene ring is fused with the skeleton of the naturally occurring …

LTX-315 is a clinical-stage, anticancer peptide therapeutic that disrupts cancer cell
membranes. Existing mechanistic knowledge about LTX-315 has been obtained from cell …