Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents
S Prachayasittikul, R Pingaew… - Mini Reviews in …, 2017 - ingentaconnect.com
Background: Cancer has been considered to be a global health concern due to the impact of
disease on the quality of life. The continual increase of cancer cases as well as the …
disease on the quality of life. The continual increase of cancer cases as well as the …
Fused and substituted pyrimidine derivatives as profound anti-cancer agents
N Abbas, GSP Matada, PS Dhiwar… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
The rationale behind drug design is the strategic utilization of heterocyclic fragments with
specific physicochemical properties to form molecular targeted agents. Among the …
specific physicochemical properties to form molecular targeted agents. Among the …
Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular …
New anticancer agents are highly needed to overcome cancer cell resistance. A novel
series of pyrimidine pyrazoline-anthracene derivatives (PPADs)(4a-t) were designed and …
series of pyrimidine pyrazoline-anthracene derivatives (PPADs)(4a-t) were designed and …
Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFR WT/COX-2 inhibitors with docking studies
A novel series of pyrimidine-5-carbonitrile derivatives was designed, synthesized, then
evaluated for their cytotoxic activity as novel anti-cancer with dual EGFRWT/COX-2 …
evaluated for their cytotoxic activity as novel anti-cancer with dual EGFRWT/COX-2 …
Design, synthesis and anticancer activity of benzofuran derivatives targeting VEGFR-2 tyrosine kinase
Two series of chalcone and thiopyrimidine benzofuran derivatives were designed,
synthesized and evaluated in vitro for their vascular endothelial growth factor receptor …
synthesized and evaluated in vitro for their vascular endothelial growth factor receptor …
Novel indolyl-pyrimidine derivatives: synthesis, antimicrobial, and antioxidant evaluations
MS Mohamed, MM Youns, NM Ahmed - Medicinal Chemistry Research, 2014 - Springer
In the present study, a novel series of indolyl-pyrimidines (1–13) were synthesized starting
from 4-hydrazinopyrimidine-5-carbonitrile 3. Elemental analysis, IR, 1 H-NMR, 13 C-NMR …
from 4-hydrazinopyrimidine-5-carbonitrile 3. Elemental analysis, IR, 1 H-NMR, 13 C-NMR …
Novel Pyrimidine-5-Carbonitriles as potential apoptotic and antiproliferative agents by dual inhibition of EGFRWT/T790M and PI3k enzymes; Design, Synthesis …
Abstract A new series of 6-(4-fluorophenyl)-2-(methylthio) pyrimidine-5-carbonitrile
derivatives were designed and synthesized as EGFR/PI3K dual inhibitors, and potential …
derivatives were designed and synthesized as EGFR/PI3K dual inhibitors, and potential …
Synthesis of novel substituted tetrahydropyrimidine derivatives and evaluation of their pharmacological and antimicrobial activities
NFH Mahmoud, EA Ghareeb - Journal of heterocyclic chemistry, 2019 - Wiley Online Library
Tetrahydropyrimidine derivative 1 was employed as intermediate compound, which in turn
was allowed to react with different electrophilic and nucleophilic reagents to synthesize new …
was allowed to react with different electrophilic and nucleophilic reagents to synthesize new …
Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives
MS Mohamed, MM Youns, NM Ahmed - European Journal of Medicinal …, 2013 - Elsevier
Abstract A series of 6-aryl-5-cyano thiouracil derivatives (2a-c to 11a-c) was synthesized
from 6-aryl-4-hydrazino-2-thioxo-1, 2-dihydropyrimidine-5-carbonitriles (1a-c). The products …
from 6-aryl-4-hydrazino-2-thioxo-1, 2-dihydropyrimidine-5-carbonitriles (1a-c). The products …
Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia …
NM Ahmed, MS Mohamed, SM Awad… - Journal of Enzyme …, 2024 - Taylor & Francis
Herein, a novel series of 6-amino-5-cyano-2-thiopyrimidines and condensed pyrimidines
analogues were prepared. All the synthesized compounds (1a-c, 2a-c, 3a-c, 4a-r and 5a-c) …
analogues were prepared. All the synthesized compounds (1a-c, 2a-c, 3a-c, 4a-r and 5a-c) …