New insights into the function and pathophysiology of the ectodomain sheddase A Disintegrin And Metalloproteinase 10 (ADAM10)

D Rosenbaum, P Saftig - The FEBS journal, 2024 - Wiley Online Library
The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …

A Sequential Dual Functional Supramolecular Hydrogel with Promoted Drug Release to Scavenge ROS and Stabilize HIF‐1α for Myocardial Infarction Treatment

K Wang, SY Yao, Z Wang, L Shen… - Advanced …, 2024 - Wiley Online Library
Myocardial infarction (MI) has a characteristic inflammatory microenvironment due to the
overproduction of reactive oxygen species (ROS) and causes the extraordinary deposition of …

[HTML][HTML] CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization

XW Gao, HL Hu, MH Xie… - Experimental and …, 2023 - spandidos-publications.com
Abstract CX3C chemokine ligand 1 (CX3CL1) belongs to the CX3C chemokine family and is
involved in various disease processes. However, its role in intervertebral disc degeneration …

Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis

JH Gao, AD He, LM Liu, YJ Zhou, YW Guo, M Lu… - Cancer Letters, 2024 - Elsevier
Metastasis is the main culprit of cancer-related death and account for the poor prognosis of
hepatocellular carcinoma. Although platelets have been shown to accelerate tumor cell …

A universal strategy for constructing high-performance silica-based AIE materials for biomedical application

Y Zhang, R Miao, H Sha, W Ma, Y Huang… - Journal of Colloid and …, 2024 - Elsevier
As an emerging fluorophore, aggregation-induced emission luminogens (AIEgens) have
received widespread attention in recent years, but the inherent drawbacks of AIEgens, such …

[HTML][HTML] A methodology to globally assess ectodomain shedding using soluble fractions from the mouse brain

M Lobete, T Salinas, S Izquierdo-Bermejo… - Frontiers in …, 2024 - frontiersin.org
Ectodomain shedding (ES) is a fundamental process involving the proteolytic cleavage of
membrane-bound proteins, leading to the release of soluble extracellular fragments (shed …

Investigation of mesalazine as an antifibrotic drug following myocardial infarction in male mice

SR Künzel, L Winter, M Hoffmann, TA Kant… - Physiological …, 2023 - Wiley Online Library
Objectives Myocardial infarction (MI) initiates a complex reparative response during which
damaged cardiac muscle is replaced by connective tissue. While the initial repair is …

[HTML][HTML] Prognostic Value of A Disintegrin and Metalloproteinase Domain-8 in Heart Failure

Z Ji, J Guo, Y Xu, W Zuo, R Zhang, A Carvalho… - Heliyon, 2024 - cell.com
Background Heart failure (HF) is a severe disease threatening people's health. The aim of
this study is to find a significant biomarker inducive to predicting the prognosis of HF …

ADAM10 Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Activating the Notch Signaling Pathway

T Xu, S Jiang, T Liu, S Han, Y Wang - Cell Biochemistry and Biophysics, 2024 - Springer
The occurrence of myocardial ischemia/reperfusion injury is commonly observed during
cardiac surgery; however, there remains a dearth of effective therapeutic strategies to …

Redirecting full-length FLT1 expression towards its soluble isoform promotes postischemic angiogenesis

M Bundalo, S Vorlova, J Ulrich, R Barbieri, L Richter… - bioRxiv, 2024 - biorxiv.org
Vascular endothelial growth factors and their tyrosine kinase receptors are key mediators of
vasculogenesis and angiogenesis with FLT1 (VEGFR1) serving as a decoy receptor. A …