Cytoskeletal actin dynamics is essential for T cell activation. Here, we show evidence that
the binding kinetics of the antigen engaging the T cell receptor influences the nanoscale …

HIV-1 Gag protein assembles at the plasma membrane of infected cells for viral particle
formation. Gag targets lipids, mainly PI (4, 5) P2, at the inner leaflet of this membrane. Here …

Cholesterol constitutes∼ 30–40% of the mammalian plasma membrane, a larger fraction
than of any other single component. It is a major player in numerous signaling processes as …

An Introduction to Fluorescence Correlation Spectroscopy represents a comprehensive
introduction to fluorescence correlation spectroscopy (FCS), a biophysical experimental …

Single-particle tracking (SPT) has become a powerful tool to quantify transport phenomena
in complex media with unprecedented detail. Based on the reconstruction of individual …

Activation of immune cells relies on a dynamic actin cytoskeleton. Despite detailed
knowledge of molecular actin assembly, the exact processes governing actin organization …

Cells crucially rely on the interactions of biomolecules at their plasma membrane to maintain
homeostasis. Yet, a methodology to systematically quantify biomolecular organisation …

Naltrexone (NTX), a homolog of the opiate antidote naloxone, is an orally active long-acting
general opioid receptor antagonist used in the treatment of opiate dependence. NTX is also …

Invariant NKT (iNKT) cells have the unique ability to shape immunity during antitumor
immune responses and other forms of sterile and nonsterile inflammation. Recent studies …

Cellular function is reliant on the dynamic interplay between the plasma membrane and the
actin cytoskeleton. This critical relationship is of particular importance in immune cells …