The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …

Detection of microbial nucleic acids by the innate immune system is mediated by numerous
intracellular nucleic acids sensors. Upon the detection of nucleic acids these sensors induce …

Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain
lesions, multifocal white matter alterations, cerebral atrophy, and severe psychomotor …

The rat has been extensively used as a small animal model. Many genetically engineered
rat models have emerged in the last two decades, and the advent of gene-specific …

The contribution of microglia in neurological disorders is emerging as a leading disease
driver rather than a consequence of pathology. RNAseT2‐deficient leukoencephalopathy is …

Abstract RNASET2 (Ribonuclease T2) functions as a tumor suppressor in preventing
ovarian tumorigenesis. However, the mechanisms underlying the regulation of RNASET2 …

The rat is an important animal model for understanding gene function and developing
human disease models. Knocking out a gene function in rats was difficult until recently …

The laboratory rat continues to be the model of choice for many studies of physiology,
behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; …

Activation of microglial cells accompanies the progression of many neurodegenerative
disorders, including Alzheimer's disease (AD). Development of molecular imaging tools …

RNase T2, a ubiquitously expressed RNase, degrades RNAs in the endosomal
compartments. RNA sensors, double-stranded RNA (dsRNA)-sensing Toll-like receptor 3 …